Posts tagged cirrhosis
Complications of Cirrhosis: Part 1
Complications of Cirrhosis: Part 1

The poor liver is always neglected. The kidneys get all the attention with equations and renal dosing adjustments, but the liver is left with vague mild/moderate/severe recommendations. BUT NOT TODAY. Today is viva la liver day! Join tl;dr as we take a journey through the pathophysiology of cirrhosis and its associated major complications.

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Clinical, Pharmacy School, Practice, ResidencyStephanie Kujawskiliver, fibrosis, cirrhosis, portal hypertension, ascites, SBP, HRS, hepatic encephalopathy, variceal bleeding, varices, RAAS, splanchnic vasodilation, liver anatomy for pharmacists, liver anatomy, what is cirrhosis, portal hypertension treatment, portal hypertension pathophysiology, RAAS system, RAAS pathway, complications of cirrhosis, ascites management, ascites treatment, ascites drug therapy, SPB prophylaxis, SBP treatment, spontaneous bacterial peritonitis pathology, pharmacologic management of SBP, secondary prevention of SBP, primary prevention of SBP, prophylactic regimens for SBP
Using Direct Oral Anticoagulants in Special Populations
Using Direct Oral Anticoagulants in Special Populations

For all those times you wished someone could just give you the DL on whether or not you could recommend a DOAC… HERE IT IS! Seriously the best overview of the current lit you could ask for. Read it. Absorb it. Explore it. Use it.

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Clinical, Pharmacy School, Practice, ResidencyStephanie Kujawskianticoagulation, DOAC, NOAC, apixaban, rivaroxaban, edoxaban, pregnancy, obesity, mechanical heart valve, dialysis, liver dysfunction, cirrhosis, atrial fibrillation, venous thromboembolism, dabigatran
New FDA Approval - Epclusa
New FDA Approval - Epclusa

Drug

sofosbuvir / velpatasvir [Epclusa]

Indication

Epclusa is used for treatment of chronic hepatitis C (HCV). It can be used in patients both with and without cirrhosis. If the patient does have cirrhosis (moderate to severe), Epclusa should be given with ribavirin. 

Eplcusa can be given all by its lonesome self if there is no cirrhosis or if cirrhosis is in earlier stages. 

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FDA Approval, Clinical, PracticeBrandon DysonHepatitis C, Harvoni, HCV, HepC, sofosbuvir, velpatasvir, epclusa, FDA approval, new drug, cirrhosis