First, we gave you the dosing guide. Then, we gave you the drug interactions. You thought that was all there is to warfarin? Now you can have it ALL in this definitive guide to the one and only warfarin.
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If you are a future (or current) pharmacist, you need to know warfarin. You don't need me to tell you that. Every teacher and preceptor you've had since you started school has been drilling that into your head.
However you've probably also noticed that few will actually tell you how to dose warfarin. Sure, you learn about purple toes and birth defects, but that doesn't tell you what to do when your patient's INR is 5.6.
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Imagine it's your first week of an APPE rotation at an anticoagulation clinic. You're excited and a little nervous. You've been brushing up on your Lovenox. You've read all you can about Eliquis and Xarelto and Pradaxa (oh my!). You're ready to impress.
Then there's the elephant in the room that is warfarin. Sure, you know lots about it. You can rattle off facts about VKORC1, and R and S enantiomers. You know that the pills are color coded by strength.
But how do you actually dose warfarin? If you're like most of us, you probably don't feel adequately prepared to jump right into managing wafarin therapy with what you learned in the classroom.
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